Genetic changes associated with testicular cancer susceptibility

cause or effect: which genetic changes are associated with cancer?

Susceptibility genetic variants associated with early-onset colorectal cancer.

Colorectal cancer (CRC) is the second most common cancer in Western countries. Hereditary forms only correspond to 5% of CRC burden. Recently, genome-wide association studies have identified common low-penetrant CRC genetic susceptibility loci. Early-onset CRC (CRC<50 years old) is especially suggestive of hereditary predisposition although 85-90% of heritability still remains unidentified. CRC...

Genetic susceptibility variants associated with colorectal cancer prognosis.

Colorectal cancer (CRC) is the second leading cause of cancer-related death among men and women in Western countries. Once a tumour develops, a differentiated prognosis could be determined by lifestyle habits or inherited and somatic genetic factors. Finding such prognostic factors will be helpful in order to identify cases with a shorter survival or at a higher risk of recurrence that may bene...

Genetic Variants Associated with Colorectal Adenoma Susceptibility

BACKGROUND Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. AIM To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (≥ 3 adenomas). METHODS We selected 1,326 patients with increased risk for advanced adeno...

Genetic factors associated with susceptibility to obesity

This review discusses the various genetic factors and gene products (proteins) related to obesity. The three fundamental mechanisms underlying obesity are: relative increase in energy intake; reLative decrease in energy expenditure; and preferential partitioning of ingested calories to fat storage. Gene defects can be related to any one of these mechanisms, either alone or together. Many geneti...